memory and its disorders
Our laboratory at UCLA is studying learning, memory and its disorders.
Our field of study is Molecular and Cellular Cognition. The goal of this field is to derive explanations of cognitive processes that integrate molecular, cellular, circuit and behavioral mechanisms and to find treatments for cognitive disorders. We are part of the UCLA Integrative Center for Learning and Memory
- We are searching for molecular, cellular and circuit processes that underlie the encoding, allocation, storage and recall of information in the brain.
- Insights into mechanisms of memory are being used to unravel the causes and develop treatments for cognitive deficits associated with aging, Intellectual disabilities, autism and schizophrenia. Recently, our studies in mice suggested that it is possible to reverse neurodevelopmental disorders, such as Intellectual disabilities associated with TSC and NF1, in adults.
- Additionally, we hope our studies of the mechanisms underlying extraordinary cognitive function may lead to general treatments for cognitive disorders and to faster recovery after brain injury.
- Our laboratory is developing strategies to derive simplified useful representations of previous findings (i.e. research maps) that could be used for integrating and planning experiments.
- New Nature Reviews Neuroscience article on synaptic tagging during memory allocation (PDF)
- New Symposium: Tools for integrating and planning experiments in neuroscience (NRB auditorium, UCLA, March 11, 2014). It is free, but registration is required.
- New Neuron paper on Research Maps (PDF)
- New Book: Engineering the next revolution in neuroscience: the new science of experiment planning
- New Neuron paper on the importance of adult born neurons for psychiatric disorders (PDF)
- New Mol Psych paper on the interaction between TSC and gestational immune activation in autism (PDF)
- New PNAS research paper on human and mouse studies of the role of neurofibromin in prefrontal cortical function (PDF)
- New Current Biology paper on the biology of remote memory (PDF)
- New Annual Reviews of Neuroscience on learning disabilities associated with NF1 ((PDF)
- New Science article on memory allocation (PDF)