Memory Allocation

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Recent findings from our laboratory (to download (</B><A HREF="http://www.silvalab.com.cnchost.com/silvapapers/SheenaCREB2007.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv"><B>PDF</B></A><B>) unraveled the first insights into the processes that modulate memory allocation in neuronetworks. They showed that neurons in the lateral amygdala compete to take part in auditory fear conditioned memory traces and that the levels of the transcription factor CREB (cAMP-response element binding protein) can affect the probability of a neuron to be recruited into a given memory representation. We are currently determining how the molecular and cellular mechanisms of memory allocation affect the storage and retrieval of information in the brain.</B></div> <bR> <div> <B><U>Key reference</U></B></div> <div> <B>Jin-Hee Han, Steven A. Kushner, Adelaide P. Yiu, Christy A. Cole, Anna Matynia, Robert A.</B></div> <div> <B>Brown, Rachael Neve, John F. Guzowski, Alcino J. Silva, Sheena A. Josselyn. Neuronal competition and selection during memory formation. Science (</B><A HREF="http://www.silvalab.com.cnchost.com/silvapapers/SheenaCREB2007.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv"><B>PDF</B></A><B>). </B></div> <bR> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 184 WIDTH="769"><bR> <div> For descriptions of our other projects click on one of the links below...</div> <bR> <div> <A HREF="aging.htm" TARGET="_top" TITLE="Aging and Cognition">Aging and Cognition</A>   ·   <A HREF="camkii.htm" TARGET="_top" TITLE="CaMKII and Learning">CaMKII and Learning</A>   ·   <A HREF="enhancements.htm" TARGET="_top" TITLE="Cognitive enhancements">Cognitive enhancements</A>   ·   <A HREF="cortical.htm" TARGET="_top" TITLE="Cortical memories">Cortical memories</A>   ·   <A HREF="recovery.htm" TARGET="_top" TITLE="Enhancing plasticity and recovery">Enhancing plasticity and recovery</A>   ·   <A HREF="ld.htm" TARGET="_top" TITLE="Learning disabilities">Learning disabilities</A>   ·   <B>Memory Allocation</B>   ·   <A HREF="genes.htm" TARGET="_top" TITLE="Novel memory genes">Novel memory genes</A>   ·   <A HREF="schizophrenia.htm" TARGET="_top" TITLE="Schizophrenia">Schizophrenia</A>   ·   <A HREF="s2.htm" TARGET="_top" TITLE="Science of Science">Science of Science</A></div> </tD> </tR> <tR> <tD VALIGN=TOP BGCOLOR=#FFFFFF HEIGHT= 162 WIDTH="769"><bR> <bR> <bR> <bR> <div> <A HREF="projects.htm" TARGET="_top" TITLE="Projects ">Projects </A>   ·   <A HREF="approaches.htm" TARGET="_top" TITLE="Approaches">Approaches</A>   ·   <A HREF="publications.htm" TARGET="_top" TITLE="Publications">Publications</A>   ·   <A HREF="personnel.htm" TARGET="_top" TITLE="Lab Members">Lab Members</A>   ·   <A HREF="alcino.htm" TARGET="_top" TITLE="Alcino J. 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