From Molecules to Cognition
Our laboratory uses a number of state-of-the-art approaches to study cognitive function
at multiple levels of analyses, from molecules to cognition
We take advantage of a number of molecular and genomic (i.e., single cell sequencing, RNAseq, proteomics, etc.) strategies to track and alter molecular function in the brain, including molecular sensors for imaging studies, optogenetic manipulations of molecular function.etc.
We are using a number of state of the art approaches, such as optogenetics, chemogenetics, circuit tracing, time-lapse two-photon imaging in vivo, dendritic functional imaging, our own head-mounted fluorescent microscopes in freely moving mice (2018 method of the year!) to define the cellular and circuit interactions involved in memory. We also use a number of electrophysiological approaches to study the cell biology of learning and memory. With head-mounted fluorescent microscopes we engineered at UCLA, we are carrying out in vivo imaging of hippocampal and cortical circuits in freely behaving mice! These head-mounted fluorescent microscopes are giving us unprecedented access to the workings of neurocircuits in freely behaving mice!
Most of our studies start with extensive behavioral analyses. For this purpose our laboratory uses a number of freely behaving and head attached behavioral tests that allow us to evaluate a wide range of rodent behaviors. We are also engaged in collaborative cognitive neuroscience studies of patients using techniques such as brain imaging
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