Silvalab

<body topmargin=0 leftmargin=0 marginheight=0 marginwidth=0> <table cellpadding=0 cellspacing=0 border=0 height="100%"><tr> <td valign="top" width=12.5% BGCOLOR="#FFFFFF" TEXT="#080000"> <bR> </td> <td valign="top" width="100%" style=" border-top: 26px solid #FFFFFF; border-left: 63px solid #FFFFFF;border-right: 63px solid #FFFFFF;" BGCOLOR="#FFFFFF" TEXT="#080000"> <div> <B> <TABLE BORDER="1" CELLPADDING="4" CELLSPACING="4" WIDTH="800" BORDERCOLORLIGHT="#808080" BORDERCOLORDARK="#FFFFFF" FRAME="BOX" RULES="ALL" HSPACE="0" VSPACE="0" > <tR> <tD VALIGN=TOP COLSPAN=4 BGCOLOR=#DDDDDD HEIGHT= 76 ><NOBR><div> <B><IMG SRC="14860c470.png" border=0 width="780" height="71" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></div> </NOBR></tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=4 BGCOLOR=#BBBBBB HEIGHT= 30 ><NOBR><div> <B> </B><A HREF="projects.htm" TARGET="_top" TITLE="Projects "><B><IMG SRC="147e61190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="approaches.htm" TARGET="_top" TITLE="Approaches"><B><IMG SRC="147f61190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="publications.htm" TARGET="_top" TITLE="Publications"><B><IMG SRC="148061190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="personnel.htm" TARGET="_top" TITLE="Lab Members"><B><IMG SRC="148161190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="alcino.htm" TARGET="_top" TITLE="Alcino J. Silva"><B><IMG SRC="148261190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="funding.htm" TARGET="_top" TITLE="Awards"><B><IMG SRC="148361190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="positions.htm" TARGET="_top" TITLE="Open Positions"><B><IMG SRC="148461190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="aboutus.htm" TARGET="_top" TITLE="aboutus"><B><IMG SRC="148561190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A></div> </NOBR></tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=4 BGCOLOR=#6666CC HEIGHT= 14 WIDTH="756"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="14" ALIGN="bottom" WIDTH="756" HSPACE="0" VSPACE="0"></tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=4 BGCOLOR=#EEEEEE HEIGHT= 472 WIDTH="756"><div> <IMG SRC="1339d4f90.jpg" border=0 width="212" height="249" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></div> <div> Memory and how it fails...</div> <bR> <div> The Silvalab is studying learning, memory and its disorders, including cognitive deficits associated with <A HREF="aging.htm" TARGET="_top" TITLE="Aging and Cognition">aging</A>, <A HREF="ld.htm" TARGET="_top" TITLE="Learning disabilities">learning disabilities</A> and <A HREF="schizophrenia.htm" TARGET="_top" TITLE="Schizophrenia">schizophrenia</A>.  </div> <bR> <div> Our field of study is <A HREF="http://www.molcellcog.org" TARGET="_top" TITLE="http://www.molcellcog.org"><B>Molecular and Cellular Cognition</B></A>. The goal of this field is to derive explanations of cognitive processes that integrate molecular, cellular, and behavioral mechanisms and to find treatments for cognitive disorders.</div> </tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=4 HEIGHT= 34 WIDTH="756"><bR> <bR> </tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=2 HEIGHT= 614 WIDTH="500"><div> <B><IMG SRC="13eb17950.jpg" border=0 width="279" height="149" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></div> <bR> <div> Highlights</div> <bR> <div> <IMG BORDER="0" SRC="Symb075c00b700f000000000.png" HEIGHT="16" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">We are searching for molecular, cellular and circuit processes that underlie the encoding, <A HREF="allocation.htm" TARGET="_top" TITLE="Memory Allocation">allocation</A>, <A HREF="genes.htm" TARGET="_top" TITLE="Novel memory genes">storage</A> and recall of information in the brain. </div> <div> <IMG BORDER="0" SRC="Symb075c00b700f000000000.png" HEIGHT="16" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Additionally, we hope our studies of the mechanisms underlying <A HREF="recovery.htm" TARGET="_top" TITLE="Enhancing plasticity and recovery">extraordinary cognitive function </A>may lead to general treatments for cognitive disorders.</div> <div> <IMG BORDER="0" SRC="Symb075c00b700f000000000.png" HEIGHT="16" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">We are using insights into mechanisms of memory to unravel the causes and develop treatments for cognitive deficits associated with <A HREF="aging.htm" TARGET="_top" TITLE="Aging and Cognition">aging</A>, <A HREF="ld.htm" TARGET="_top" TITLE="Learning disabilities">learning disabilities</A> and <A HREF="schizophrenia.htm" TARGET="_top" TITLE="Schizophrenia">schizophrenia</A>.  </div> <div> <IMG BORDER="0" SRC="Symb075c00b700f033333300.png" HEIGHT="16" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Key components of our work on <A HREF="cortical.htm" TARGET="_top" TITLE="Cortical memories">remote memory</A> are carried out within a collaborative network, the <A HREF="cpm.htm" TARGET="_top" TITLE="CPM">NIMH Silvio O. Conte Center for Plasticity and Memory (CPM)</A>. Together with the labs of Michael Stryker, Kevin Fox and Joshua Trachtenberg, we are unraveling the molecular basis of cortical plasticity</div> <bR> <bR> <bR> </tD> <tD VALIGN=TOP WIDTH="32"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="614" ALIGN="bottom" WIDTH="32" HSPACE="0" VSPACE="0"></tD> <tD VALIGN=TOP WIDTH="212"><bR> <div> <IMG SRC="14056b500.jpg" border=0 width="107" height="80" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></div> <div> Treating Learning Disabilities!</div> <div> Our lab just developed treatments in mice  for <A HREF="nf1.htm" TARGET="_top" TITLE="Neurofibromatosis Type I">NF1 </A> and <A HREF="tsc.htm" TARGET="_top" TITLE="TSC">Tuberous Sclerosis</A>.<FONT SIZE="2" COLOR="#CC6666" FACE="Calibri" > see more<A HREF="ld.htm" TARGET="_top" TITLE="Learning disabilities">>></A></FONT></div> <bR> <div> <IMG SRC="13ed6a8a0.jpg" border=0 width="106" height="138" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></div> <div> Extraordinary cognition.<FONT SIZE="5" COLOR="#000000" FACE="Calibri" > </FONT></div> <div> <FONT SIZE="2" COLOR="#3300CC" FACE="Calibri" >Understanding extraordinary brains may allow us to develop cognitive treatments.</FONT> See more <A HREF="enhancements.htm" TARGET="_top" TITLE="Cognitive enhancements">>></A><FONT SIZE="4" COLOR="#000000" FACE="Calibri" > </FONT></div> <bR> <div> <A HREF="genes.htm" TARGET="_top" TITLE="Novel memory genes"><IMG SRC="140472500.jpg" border=0 width="114" height="80" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></A>  </div> <div> <FONT SIZE="4" COLOR="#000000" FACE="Calibri" >Memory genes. </FONT>see more<A HREF="genes.htm" TARGET="_top" TITLE="Novel memory genes">>></A><FONT SIZE="3" COLOR="#FF0000" FACE="Calibri" >      </FONT></div> </tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=2 HEIGHT= 508 WIDTH="500"><div> <B><IMG SRC="13f6506c0.gif" border=0 width="80" height="108" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"> <IMG SRC="13f8506b0.jpg" border=0 width="80" height="107" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"><IMG SRC="13fa50690.gif" border=0 width="80" height="105" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"><IMG SRC="13fc506a0.jpg" border=0 width="80" height="106" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"><IMG SRC="13fe506a0.jpg" border=0 width="80" height="106" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"><IMG SRC="1401506a0.jpg" border=0 width="80" height="106" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></div> <bR> <div> New papers and more:</div> <bR> <div> <B>1- New Nature Medicine paper on the mechanism and treatment for cognitive deficits in TSC (</B><A HREF="http://www.silvalab.com.cnchost.com/silvapapers/DanNM2008.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv"><B>Click Here</B></A><B>)</B></div> <bR> <div> <B>2- New JAMA paper with a promising treatment for NF1  (</B><A HREF="http://www.silvalab.com.cnchost.com/silvapapers/YpeJAMA2008.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv"><B>PDF</B></A><B>)</B></div> <bR> <div> <B>3- New Plos paper on novel approach to screen for remote memory mutants (</B><A HREF="http://www.silvalab.com.cnchost.com/silvapapers/DanNM2008.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv"><B>PDF</B></A><B>)</B></div> <bR> <div> <B>4- New JP paper on the science of research (</B><A HREF="http://www.silvalab.com.cnchost.com/silvapapers/silvajp2008.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv"><B>PDF</B></A><B>)</B></div> <bR> <div> <B>5- New JN paper on the role NMDAR/CaMKII interactions. (</B><A HREF="http://www.silvalab.com.cnchost.com/silvapapers/ZhouJN2007.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv"><B>PDF</B></A><B>)</B></div> <bR> <div> <B>6- New PNAS paper on an animal model of Schizophrenia (</B><A HREF="http://www.silvalab.com.cnchost.com/silvapapers/LiPNAS2007.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv"><B>PDF</B></A><B>)</B></div> <bR> </tD> <tD VALIGN=TOP WIDTH="32"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="508" ALIGN="bottom" WIDTH="32" HSPACE="0" VSPACE="0"></tD> <tD VALIGN=TOP WIDTH="212"><bR> <div> <A HREF="approaches339.htm" TARGET="_top" TITLE="in vivo Imaging"><B><IMG SRC="140273560.jpg" border=0 width="115" height="86" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A></div> <div> Watching neurons...<FONT SIZE="5" COLOR="#000000" FACE="Calibri" > </FONT></div> <div> <FONT SIZE="2" COLOR="#3300CC" FACE="Calibri" >Our laboratory is using state-of-the art imaging techniques to study neurons in living mice!</FONT><FONT SIZE="2" COLOR="#CCCCE4" FACE="Calibri" > </FONT>see more<A HREF="approaches339.htm" TARGET="_top" TITLE="in vivo Imaging">>></A></div> <bR> <bR> <div> <A HREF="allocation.htm" TARGET="_top" TITLE="Memory Allocation"><IMG SRC="140379440.png" border=0 width="121" height="68" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></A></div> <div> What determines where memories are stored? </div> <div> <FONT SIZE="2" COLOR="#3300CC" FACE="Calibri" >When a network is engaged in memory storage, only some neurons become committed. Recently, we discovered the first molecular  mechanism that determines whether a neuron engages in a given memory. </FONT>see more<A HREF="allocation.htm" TARGET="_top" TITLE="Memory Allocation">>></A></div> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 288 WIDTH="243"><div> <B> </B> <A HREF="alcino.htm" TARGET="_top" TITLE="Alcino J. Silva"><IMG SRC="141a73ac0.jpg" border=0 width="115" height="172" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></A></div> <div> <FONT SIZE="5" COLOR="#000000" FACE="Calibri" ><A HREF="alcino.htm" TARGET="_top" TITLE="Alcino J. Silva">Alcino J. Silva</A></FONT><FONT SIZE="4" COLOR="#000000" FACE="Calibri" > </FONT>is a  professor in the Departments of <A HREF="http://www.neurobio.ucla.edu/nb/" TARGET="_top" TITLE="http://www.neurobio.ucla.edu/nb/">Neurobiology</A>, <A HREF="http://www.psychiatry.ucla.edu/" TARGET="_top" TITLE="http://www.psychiatry.ucla.edu/">Psychiatry</A> and <A HREF="http://www.psych.ucla.edu/" TARGET="_top" TITLE="http://www.psych.ucla.edu/">Psychology</A>. </div> <div> We are also affiliated with the <A HREF="http://www.bri.ucla.edu/" TARGET="_top" TITLE="http://www.bri.ucla.edu/">Brain Research Institute</A>.   </div> </tD> <tD VALIGN=TOP WIDTH="251"><div> <A HREF="personnel.htm" TARGET="_top" TITLE="Lab Members"><B><IMG SRC="1335fdaa0.jpg" border=0 width="253" height="170" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><FONT SIZE="4" COLOR="#000000" FACE="Calibri" >                                                                       </FONT></div> <div> Our group...    </div> <div> ...and some of our youngest post-docs..<B>.</B><FONT SIZE="2" COLOR="#000000" FACE="Calibri" ><B> </B></FONT></div> </tD> <tD VALIGN=TOP WIDTH="32"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="288" ALIGN="bottom" WIDTH="32" HSPACE="0" VSPACE="0"></tD> <tD VALIGN=TOP WIDTH="212"><bR> <div> <A HREF="contact_us.htm" TARGET="_top" TITLE="Contact us"><IMG SRC="139f527b0.jpg" border=0 width="82" height="123" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></A></div> <div> <FONT SIZE="5" COLOR="#000000" FACE="Calibri" >Our laboratory</FONT><FONT SIZE="5" COLOR="#333333" FACE="Calibri" > </FONT>is located in the <A HREF="http://www.gonda.ucla.edu/" TARGET="_top" TITLE="http://www.gonda.ucla.edu/">Gonda Neuroscience and Genetics Center</A> and our behavioral facilities are housed in <A HREF="http://www.psych.ucla.edu/" TARGET="_top" TITLE="http://www.psych.ucla.edu/">Department of Psychology</A>'s Franz Hall. </div> <div>                </div> <bR> </tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=4 HEIGHT= 174 WIDTH="756"><bR> <bR> <div> <A HREF="contact_us.htm" TARGET="_top" TITLE="Contact us">How to contact us</A></div> <bR> <bR> <bR> <div> <A HREF="projects.htm" TARGET="_top" TITLE="Projects ">Projects </A>   ·   <A HREF="approaches.htm" TARGET="_top" TITLE="Approaches">Approaches</A>   ·   <A HREF="publications.htm" TARGET="_top" TITLE="Publications">Publications</A>   ·   <A HREF="personnel.htm" TARGET="_top" TITLE="Lab Members">Lab Members</A>   ·   <A HREF="alcino.htm" TARGET="_top" TITLE="Alcino J. Silva">Alcino J. Silva</A>   ·   <A HREF="funding.htm" TARGET="_top" TITLE="Awards">Awards</A>   ·   <A HREF="pictures.htm" TARGET="_top" TITLE="Lab Pictures">Lab Pictures</A>   ·   <A HREF="positions.htm" TARGET="_top" TITLE="Open Positions">Open Positions</A>   ·   <A HREF="aboutus.htm" TARGET="_top" TITLE="aboutus">aboutus</A>   ·   <A HREF="contact_us.htm" TARGET="_top" TITLE="Contact us">Contact us</A></div> </tD> </tR> </TABLE></B></div> <bR> <bR> <bR> <div> Web site by Alcino Silva</div> <bR> <bR> <bR> <bR> </td> </tr></table></body>