Our laboratory is interested in unraveling the molecular, cellular and systems mechanisms responsible for remote memory storage in neocortcal networks.
Although there is very little known about how our oldest memories are stored, our laboratory has already demonstrated the involvement of specific molecular processes and physiological mechanisms in this fascinating phase of memory.
We have a long standing collaboration with the laboratories of Joshua Trachtenberg, Kevin Fox, and Michael Stryker on molecular and cellular mechanisms involved in cortical plasticity. Our results suggest that these mechanisms have a central role in remote memory.
Matynia, A., S.G. Anagnostaras, B.J. Wiltgen, M. Lacuesta, M.S. Fanselow, and A.J. Silva, A high through-put reverse genetic screen identifies two genes involved in remote memory in mice. PLoS ONE, 2008. 3(5): p. e2121.(Click Here)
Wiltgen, BJ. Silva, AJ. Memory for context becomes less specific with time Learning and Memory, 2007, 14: 313-317 (PDF).
Frankland, P.W., Y. Wang, B. Rosner, T. Shimizu, B.W. Balleine, E.M. Dykens, E.M. Ornitz, and A.J. Silva, Sensorimotor gating abnormalities in young males with Fragile X syndrome and Fmr1-knockout mice. Molecular Psychiatry, 2004, 9, 417-425.(PDF)
Anagnostaras, S.G., G.G. Murphy, S.E. Hamilton, S.L. Mitchell, N.P. Rahnama, N.M. Nathanson, and A.J. Silva, Selective cognitive dysfunction in acetylcholine M(1) muscarinic receptor mutant mice. Nat Neurosci, 2003. 6(1): p. 51-58 (PDF)
Frankland, P., C. O'Brien, M. Ohno, A. Kirkwood, and A. Silva, CaMKII-Dependent Plasticity in the neocortex is required for remote memory. Nature, 2001. 411: p. 309-13.(PDF)
Glazewski, S., K. Giese, A. Silva, and K. Fox, The role of alpha- CaMKII autophosphorylation in neocortical experience-dependent plasticity. Nature Neuroscience, 2000. 3: p. 911-918.
Kirkwood, A., A. Silva, and M.F. Bear, Age-dependent decrease of synaptic plasticity in the neocortex of alphaCaMKII mutant mice. Proc Natl Acad Sci U S A, 1997. 94(7): p. 3380-3.(PDF)
Glazewski, S., C.M. Chen, A. Silva, and K. Fox, Requirement for alpha-CaMKII in experience-dependent plasticity of the barrel cortex. Science, 1996. 272(5260): p. 421-3.
Gordon, J.A., D. Cioffi, A.J. Silva, and M.P. Stryker, Deficient plasticity in the primary visual cortex of alpha-calcium/calmodulin-dependent protein kinase II mutant mice. Neuron, 1996. 17(3): p. 491-9.