Schizophrenia

<body topmargin=0 leftmargin=0 marginheight=0 marginwidth=0> <table cellpadding=0 cellspacing=0 border=0 height="100%"><tr> <td valign="top" width=12.5% BGCOLOR="#FFFFFF" TEXT="#080000"> <bR> </td> <td valign="top" width="100%" style=" border-top: 26px solid #FFFFFF; border-left: 63px solid #FFFFFF;border-right: 63px solid #FFFFFF;" BGCOLOR="#FFFFFF" TEXT="#080000"> <bR> <div> <TABLE BORDER="1" CELLPADDING="0" CELLSPACING="0" WIDTH="785" BORDERCOLORLIGHT="#808080" BORDERCOLORDARK="#FFFFFF" FRAME="BOX" RULES="ALL" HSPACE="0" VSPACE="0" > <tR> <tD VALIGN=TOP BGCOLOR=#DDDDDD HEIGHT= 76 ><NOBR><div> <A HREF="index.htm" TARGET="_top" TITLE="Silvalab"><B><IMG SRC="14860c470.png" border=0 width="780" height="71" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A></div> </NOBR></tD> </tR> <tR> <tD VALIGN=TOP BGCOLOR=#BBBBBB HEIGHT= 30 ><NOBR><div> <B> </B><A HREF="projects.htm" TARGET="_top" TITLE="Projects "><B><IMG SRC="147e61190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="approaches.htm" TARGET="_top" TITLE="Approaches"><B><IMG SRC="147f61190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="publications.htm" TARGET="_top" TITLE="Publications"><B><IMG SRC="148061190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="personnel.htm" TARGET="_top" TITLE="Lab Members"><B><IMG SRC="148161190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="alcino.htm" TARGET="_top" TITLE="Alcino J. Silva"><B><IMG SRC="148261190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="funding.htm" TARGET="_top" TITLE="Awards"><B><IMG SRC="148361190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="positions.htm" TARGET="_top" TITLE="Open Positions"><B><IMG SRC="148461190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="aboutus.htm" TARGET="_top" TITLE="aboutus"><B><IMG SRC="148561190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A></div> </NOBR></tD> </tR> <tR> <tD VALIGN=TOP BGCOLOR=#6666CC HEIGHT= 20 WIDTH="781"><div>        <A HREF="index.htm" TARGET="_top" TITLE="Silvalab"><B>Home</B></A></div> </tD> </tR> </TABLE></div> <div> <TABLE BORDER="1" CELLPADDING="4" CELLSPACING="0" WIDTH="781" BORDERCOLORLIGHT="#330000" BORDERCOLORDARK="#FFFFFF" FRAME="BOX" RULES="ALL" HSPACE="0" VSPACE="0" BGCOLOR=#EEEEEE > <tR> <tD VALIGN=TOP BGCOLOR=#FFFFFF HEIGHT= 612 WIDTH="769"><div> <A HREF="http://images.google.com/imgres?imgurl=http://www.festomuvesz.hu/sukosd/kepek/2005_01_16/TN_Schizophrenia3.JPG&imgrefurl=http://www.festomuvesz.hu/sukosd/sukosd.htm&h=145&w=180&sz=7&tbnid=kgbbkdGIhDsJ:&tbnh=77&tbnw=96&hl=en&start=513&prev=/images%3Fq%3Dschizophrenia%26start%3D500%26svnum%3D10%26hl%3Den%26lr%3D%26sa%3DN" TARGET="_top" TITLE="http://images.google.com/imgres?imgurl=h"><IMG SRC="103f25010.jpg" border=0 width="293" height="257" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></A></div> <div> Bárkák Keringoje - Budapest, 2004</div> <bR> <div> Schizophrenia</div> <div> <B>Our laboratory has initiated a new research program to study the mechanism and develop treatments for the cognitive deficits associated with Schizophrenia. For that purpose we have derived and studied animal models with mutations, such as DISC1,  that are thought to cause the disorder in patients.  Our studies (for an example </B><A HREF="http://www.silvalab.com.cnchost.com/silvapapers/LiPNAS2007.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv"><B>Click Here</B></A><B>) show that a DISC1 inducible mutation causes cognitive, social, affective, and structural deficits in mice not unlike those seen in patients with DISC mutations. Amazingly, our studies demonstrated that this mutation only needs to be present for less than 24-hours during a critical period of post-natal development for all of these symptoms to be expressed. Thus, DISC1 mutant mice are helping us to understand this disorder, and may result in future treatments.</B></div> <bR> </tD> </tR> <tR> <tD VALIGN=TOP HEIGHT= 184 WIDTH="769"><bR> <div> For descriptions of our other projects click on one of the links below...</div> <bR> <div> <A HREF="aging.htm" TARGET="_top" TITLE="Aging and Cognition">Aging and Cognition</A>   ·   <A HREF="camkii.htm" TARGET="_top" TITLE="CaMKII and Learning">CaMKII and Learning</A>   ·   <A HREF="enhancements.htm" TARGET="_top" TITLE="Cognitive enhancements">Cognitive enhancements</A>   ·   <A HREF="cortical.htm" TARGET="_top" TITLE="Cortical memories">Cortical memories</A>   ·   <A HREF="recovery.htm" TARGET="_top" TITLE="Enhancing plasticity and recovery">Enhancing plasticity and recovery</A>   ·   <A HREF="ld.htm" TARGET="_top" TITLE="Learning disabilities">Learning disabilities</A>   ·   <A HREF="allocation.htm" TARGET="_top" TITLE="Memory Allocation">Memory Allocation</A>   ·   <A HREF="genes.htm" TARGET="_top" TITLE="Novel memory genes">Novel memory genes</A>   ·   <B>Schizophrenia</B>   ·   <A HREF="s2.htm" TARGET="_top" TITLE="Science of Science">Science of Science</A></div> </tD> </tR> <tR> <tD VALIGN=TOP BGCOLOR=#FFFFFF HEIGHT= 162 WIDTH="769"><bR> <bR> <bR> <bR> <div> <A HREF="projects.htm" TARGET="_top" TITLE="Projects ">Projects </A>   ·   <A HREF="approaches.htm" TARGET="_top" TITLE="Approaches">Approaches</A>   ·   <A HREF="publications.htm" TARGET="_top" TITLE="Publications">Publications</A>   ·   <A HREF="personnel.htm" TARGET="_top" TITLE="Lab Members">Lab Members</A>   ·   <A HREF="alcino.htm" TARGET="_top" TITLE="Alcino J. 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